Early Detection Research Network

UBE2D2

Aliases:
This biomarker is also known as:
  • UBC4/5,
  • ubiquitin-conjugating enzyme E2D 2,
  • Ubiquitin-conjugating enzyme E2(17)KB 2,
  • UBC5B,
  • Ubiquitin carrier protein D2,
  • UBC4,
  • Ubiquitin-protein ligase D2,
  • ubiquitin-conjugating enzyme E2(17)KB 2,
  • ubiquitin carrier protein D2,
  • Ubiquitin-conjugating enzyme E2-17 kDa 2,
  • E2(17)KB2,
  • ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5),
  • ubiquitin-conjugating enzyme E2 D2,
  • EC 6.3.2.19,
  • ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast),
  • UBCH4,
  • UBE2D2,
  • ubiquitin-conjugating enzyme E2-17 kDa 2,
  • PUBC1,
  • UBCH5B,
  • ubiquitin-protein ligase D2,
  • UbcH5B,

Description…

From NCBI Gene: Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: UBE2D2

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2