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TNF

Basics

Aliases:
This biomarker is also known as:
  • tumor necrosis factor alpha,
  • tumor necrosis factor,
  • TNFA,
  • tumor necrosis factor (TNF superfamily, member 2),
  • DIF,
  • TNF-a,
  • TNF-alpha,
  • APC1 protein,
  • Tumor necrosis factor ligand superfamily member 2,
  • TNF, monocyte-derived,
  • tumor necrosis factor-alpha,
  • TNF, macrophage-derived,
  • Cachectin,
  • cachectin,
  • TNFSF2,
  • TNF superfamily, member 2,

View in BioMuta

Description…

TNF (tumor necrosis factor) is a cytokine involved in many biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF belongs to the TNF superfamily. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. TNF binds to its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR, through which it functions. It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immune response to infection. This cytokine is a pyrogen, causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia. TNF has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggest this cytokine has a neuroprotective function. TNF is cleaved into two chains, tumor necrosis factor, membrane form and tumor necrosis factor, soluble form.

Attributes

QA State: Under Review
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement