Early Detection Research Network

SLC5A7

Aliases:
This biomarker is also known as:
  • high affinity choline transporter; hemicholinium-3-sensitive choline transporter,
  • SLC5A7,
  • Hemicholinium-3-sensitive choline transporter,
  • solute carrier family 5 (choline transporter), member 7,
  • CHT1,
  • HMN7A,
  • hemicholinium-3-sensitive choline transporter,
  • hCHT,
  • CHT,
  • Solute carrier family 5 member 7,
  • high affinity choline transporter 1,
  • solute carrier family 5 member 7,
  • CMS20,

Description…

From NCBI Gene: This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: SLC5A7

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2