Aliases:This biomarker is also known as:
- SLAM family member 8,
- B-lymphocyte activator macrophage expressed,
- BCM-like membrane protein,
- B lymphocyte activator macrophage expressed,
- CD353 antigen,
SLAMF8 is a membrane protein belonging to the CD2 family of cell surface proteins. This protein family is characterized by Ig domains. SLAMF8 is expressed in lymph node, spleen, thymus and bone marrow. SLAMF8 may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. There are two isoforms of this protein, produced by alternative splicing.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
BLAME expression was absent in HUVEC (human umbilical vein endothelial cells) and tumor endothelial cells, but expression was detected in tumor leukocytes as well as normal monocytes.
SLAMF8 (BLAME) was one of 13 genes out of 50 selected for further validation in PMID:21617380. SLAMF8 (BLAME) shows its highest levels of expression in tonsil and lung tissue and therefore could be suitable for abdominal imaging.