Early Detection Research Network

RPSA

Aliases:
This biomarker is also known as:
  • NEM/1CHD4,
  • laminin receptor 1,
  • 67LR,
  • ribosomal protein SA,
  • laminin receptor 1 (67kD, ribosomal protein SA),
  • LAMBR,
  • LRP,
  • RSSA,
  • LRP/LR,
  • LAMR1,
  • Laminin-binding protein precursor p40,
  • Multidrug resistance-associated protein MGr1-Ag,
  • Colon carcinoma laminin-binding protein,
  • LBP/p40,
  • 67kD, ribosomal protein SA,
  • RPSA,
  • LBP,
  • p40,
  • LamR,
  • 37LRP,
  • 34/67 kDa laminin receptor,
  • 40S ribosomal protein SA,

Description…

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The amino acid sequence of laminin receptor 1 is highly through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Cell-adhesive protein LAMR1 plays an important role in the processes of cancer proliferation, invasion and metastasis. LAMR1 antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Accepted
Type: Protein
HGNC Name: RPSA

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.
Version 5.0.2