Early Detection Research Network

RET

Aliases:
This biomarker is also known as:
  • RET,
  • Proto-oncogene c-Ret,
  • MTC1,
  • EC 2.7.10.1,
  • ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease),
  • hydroxyaryl-protein kinase,
  • RET-ELE1,
  • RET transforming sequence,
  • cadherin family member 12,
  • Cadherin family member 12,
  • MEN2B,
  • receptor tyrosine kinase,
  • PTC,
  • Hirschsprung disease 1,
  • proto-oncogene tyrosine-protein kinase receptor Ret,
  • CDHR16,
  • RET51,
  • ret proto-oncogene,
  • cadherin-related family member 16,
  • proto-oncogene c-Ret,
  • multiple endocrine neoplasia and medullary thyroid carcinoma 1,
  • MEN2A,
  • CDHF12,
  • HSCR1,

Description…

From NCBI Gene: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: RET

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2