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RASSF1

Basics

Aliases:
This biomarker is also known as:
  • tumor suppressor protein RDA32,
  • RDA32,
  • Ras association (RalGDS/AF-6) domain family member 1,
  • WUGSC:H_LUCA12.5,
  • ras association domain-containing protein 1,
  • RASSF1A,
  • 123F2,
  • cardiac-specific ras association domain family 1 protein,
  • NORE2A,
  • REH3P21,
  • pancreas-specific ras association domain family 1 protein,

View in BioMuta

Description…

RASSF1A is a potential tumor suppressor. It is required for death receptor-dependent apoptosis and mediates activation of STK4 during Fas-induced apoptosis. When associated with MOAP1, RASSF1A promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. RASSF1A inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform A of RASSF1A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Attributes

QA State: Under Review
Type: Genomic
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement