Early Detection Research Network

pleiotrophin

Aliases:
This biomarker is also known as:
  • OSF-1,
  • HBNF,
  • PTN,
  • osteoblast-specific factor 1,
  • pleiotrophin,
  • neurite growth-promoting factor 1,
  • heparin-binding growth-associated molecule,
  • pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1),
  • NEGF1,
  • Heparin-binding growth factor 8,
  • Heparin-binding brain mitogen,
  • heparin-binding neurite outgrowth-promoting factor 1,
  • heparin-binding brain mitogen,
  • HBGF8,
  • HBBM,
  • heparin-binding growth factor 8,
  • HBNF1,
  • heparin binding growth factor 8,
  • Osteoblast-specific factor 1,
  • HBGF-8,
  • heparin affin regulatory protein,
  • HBNF-1,
  • Heparin-binding growth-associated molecule,
  • HARP,
  • HB-GAM,
  • Heparin-binding neurite outgrowth-promoting factor 1,

Description…

Pleiotrophin, or PTN, is a secreted growth factor found in osteoblasts and brain tissue. PTN induces neurite outgrowth and is mitogenic for fibroblasts, epithelial, and endothelial cells. It binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: PTN

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2