Early Detection Research Network

PTEN

Aliases:
This biomarker is also known as:
  • Protein Tyrosine Phosphatase,
  • Mitochondrial PTENalpha,
  • Phosphatase And Tensin-Like Protein,
  • DEC,
  • TEP1,
  • MMAC1,
  • MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10,
  • Mitochondrial Phosphatase And Tensin Protein Alpha,
  • PTENbeta,
  • EC 3.1.3.67,
  • GLM2,
  • Mutated In Multiple Advanced Cancers 1,
  • EC 3.1.3.48,
  • Phosphatase And Tensin Homolog,
  • BZS,
  • MHAM,
  • EC 3.1.3.16,
  • Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN,
  • 10q23del,
  • CWS1,
  • PTEN1,
  • PTEN,
  • Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN,

Description…

From NCBI Gene: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Proteomic
HGNC Name: PTEN

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2