Early Detection Research Network

PPBP

Aliases:
This biomarker is also known as:
  • low-affinity platelet factor IV,
  • LDGF,
  • CTAP3,
  • TC2,
  • macrophage-derived growth factor,
  • pro-platelet basic protein,
  • connective tissue-activating peptide III,
  • thromboglobulin, beta-1,
  • CTAP-III,
  • b-TG1,
  • TC1,
  • Beta-TG,
  • PPBP,
  • B-TG1,
  • CTAPIII,
  • small inducible cytokine B7,
  • leukocyte-derived growth factor,
  • PBP,
  • THBGB1,
  • SCYB7,
  • neutrophil-activating peptide 2,
  • CXC chemokine ligand 7,
  • TGB,
  • LA-PF4,
  • NAP-2,
  • small inducible cytokine subfamily B, member 7,
  • NAP-2-L1,
  • THBGB,
  • platelet basic protein,
  • pro-platelet basic protein (chemokine (C-X-C motif) ligand 7),
  • thrombocidin 2,
  • beta-thromboglobulin,
  • CXCL7,
  • MDGF,
  • thrombocidin 1,
  • TGB1,
  • neutrophil-activating peptide-2,

Description…

CTAP-III (officially named PPBP) is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: PPBP

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2