Early Detection Research Network

OAS1

Aliases:
This biomarker is also known as:
  • 2'-5'-oligoadenylate synthetase 1, 40/46kDa,
  • 2',5'-oligo A synthetase 1,
  • 2'-5' oligoadenylate synthetase 1 p52 isoform,
  • OIASI,
  • p46/p42 OAS,
  • 2'-5' oligoadenylate synthetase 1 p48 isoform,
  • 2',5'-oligoadenylate synthetase 1 (40-46 kD),
  • OIAS,
  • 2',5'-oligoadenylate synthetase 1, 40/46kDa,
  • 2'-5'-oligoadenylate synthase 1,
  • (2-5')oligo(A) synthetase 1,
  • (2-5')oligo(A) synthase 1,
  • 2-5A synthase 1,
  • E18/E16,
  • EC 2.7.7.-,
  • 2-5A synthetase 1,
  • OAS1,
  • IFI-4,
  • 2'-5'-oligoisoadenylate synthetase 1,

Description…

From NCBI Gene: This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: OAS1

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2