Early Detection Research Network

NEK3

Aliases:
This biomarker is also known as:
  • hydroxyalkyl-protein kinase,
  • phosphorylase B kinase kinase,
  • EC 2.7.11.1,
  • MGC29949,
  • NimA-related protein kinase 3,
  • NEK3,
  • glycogen synthase A kinase,
  • never in mitosis A-related kinase 3,
  • HSPK36,
  • nimA-related protein kinase 3,
  • Never in mitosis A-related kinase 3,
  • serine/threonine-protein kinase Nek3,
  • NIMA (never in mitosis gene a)-related kinase 3,
  • HSPK 36,

Description…

From NCBI Gene: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Two functional alleles for this gene have been identified in humans. The reference genome assembly (GRCh38) represents a functional allele that is associated with the inclusion of an additional coding exon in protein-coding transcripts, compared to an alternate functional allele that lacks the exon. [provided by RefSeq, Sep 2019]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: NEK3

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2