Early Detection Research Network

MYC

Aliases:
This biomarker is also known as:
  • v-myc myelocytomatosis viral oncogene homolog (avian),
  • cmyc,
  • myc proto-oncogene protein,
  • Myc proto-oncogene protein,
  • Proto-oncogene c-Myc,
  • myc-related translation/localization regulatory factor,
  • v-myc avian myelocytomatosis viral oncogene homolog,
  • MYC,
  • Class E basic helix-loop-helix protein 39,
  • BHLHE39,
  • Transcription factor p64,
  • avian myelocytomatosis viral oncogene homolog,
  • c-Myc,
  • MRTL,
  • bHLHe39,

Description…

The oncogenic protein MYC, previously known as c-MYC, is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It participates in the regulation of gene transcription of specific target genes. MYC binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of the MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. Evidence shows that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Gene
HGNC Name: MYC

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2