Early Detection Research Network

LMNA

Aliases:
This biomarker is also known as:
  • renal carcinoma antigen NY-REN-32,
  • HGPS,
  • 70 kDa lamin,
  • prelamin-A/C,
  • FPLD2,
  • PRO1,
  • lamin,
  • lamin A/C-like 1,
  • EMD2,
  • LMNA,
  • CDCD1,
  • CMT2B1,
  • LDP1,
  • progeria 1 (Hutchinson-Gilford type),
  • FPLD,
  • CDDC,
  • FPL,
  • LGMD1B,
  • LFP,
  • LMNL1,
  • lamin A/C,
  • CMD1A,
  • cardiomyopathy, dilated 1A (autosomal dominant),
  • IDC,
  • LMNC,
  • LMN1,
  • limb girdle muscular dystrophy 1B (autosomal dominant),

Description…

From NCBI Gene: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: LMNA

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2