Early Detection Research Network

PSA

Aliases:
This biomarker is also known as:
  • hK3,
  • prostate-specific antigen,
  • Seminin,
  • Gamma-seminoprotein,
  • kallikrein 3, (prostate specific antigen),
  • KLK3,
  • Kallikrein-3,
  • prostate specific antigen,
  • seminin,
  • EC 3.4.21.77,
  • semenogelase,
  • kallikrein-3,
  • Semenogelase,
  • P-30 antigen,
  • KLK2A1,
  • PSA,
  • kallikrein-related peptidase 3,
  • gamma-seminoprotein,
  • APS,

Description…

KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are increasingly thought to be involved in carcinogenesis, and many act as cancer biomarkers. The product of the KLK3 gene is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum. KLK3, or PSA, is well known for its role in diagnosing and monitoring prostate cancer. There are several isoforms of KLK3, generated by alternate splicing and transcript variants.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: KLK3

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: One
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2