Early Detection Research Network

IL6R

Aliases:
This biomarker is also known as:
  • IL-6 receptor subunit alpha,
  • MGC104991,
  • IL-6R-1,
  • IL-6RA,
  • CD126 antigen,
  • interleukin-6 receptor subunit alpha,
  • interleukin 6 receptor,
  • IL6R,
  • Membrane glycoprotein 80,
  • IL-6R subunit alpha,
  • interleukin 6 receptor alpha subunit,
  • OTTHUMP00000217870,
  • IL6RA,
  • gp80,
  • IL-6R 1,
  • IL-6R-alpha,
  • CD126,

Description…

The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal transducer) subunit. The IL6R subunit binds to IL6 (interleukin 6) with low affinity, but does not transduce a signal. The IL6ST subunit is needed for signal activation. Impaired regulation of IL6 and IL6R have been linked to many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. Isoforms encoded by alternatively spliced transcripts have been reported. Activation of the IL6/IL6R/IL6ST complex may lead to the regulation of the immune response, acute-phase reactions, and hematopoiesis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: IL6R

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2