Aliases:This biomarker is also known as:
- IL-2 receptor subunit alpha,
- CD25 antigen,
- TAC antigen,
- IL-2R subunit alpha,
- interleukin-2 receptor subunit alpha,
- interleukin 2 receptor, alpha,
The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of IL2RA, the alpha subunit. The alpha/beta subunit heterodimer, formed by IL2RA and IL2RB, is an intermediate affinity form. The alpha/beta/gamma heterotrimer formed by IL2RA, IL2RB, and IL2RG is the high affinity form. IL2RA is normally an integral membrane protein, although soluble IL2RA has been isolated. There are known alternately-spliced versions of IL2RA mRNAs, but their functions are unknown. Mutations in the IL2RA gene are associated with diabetes mellitus insulin-dependent type 10 (IDDM10). Complications of IDDM10 can adversely affect the eyes, kidneys, nerves, and blood vessels.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
IL2RA is not a strong predictor of ovarian cancer.
Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.