Early Detection Research Network

HSPB8

Aliases:
This biomarker is also known as:
  • small stress protein-like protein HSP22,
  • HMN2,
  • CMT2L,
  • Alpha-crystallin C chain,
  • alpha-crystallin C chain,
  • HspB8,
  • Small stress protein-like protein HSP22,
  • HMN2A,
  • HSPB8,
  • E2IG1,
  • heat shock protein beta-8,
  • Protein kinase H11,
  • HSP22,
  • heat shock 22kDa protein 8,
  • E2-induced gene 1 protein,
  • H11,
  • heat shock 27kDa protein 8,
  • DHMN2,
  • CRYAC,
  • protein kinase H11,

Description…

From NCBI Gene: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Gene
HGNC Name: HSPB8

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2