Aliases:This biomarker is also known as:
- Histone H2A.V,
- H2A histone family, member V,
H2AFV is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (the octamer wraps approximately 147 bp of DNA). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Additionally, H2AFV may be involved in the formation of constitutive heterochromatin, and may be required for chromosome segregation during cell division.
|QA State:||Under Review|
There are no datasets associated with this biomarker.