Early Detection Research Network

GLDC

Aliases:
This biomarker is also known as:
  • glycine dehydrogenase (decarboxylating),
  • glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P),
  • Glycine decarboxylase,
  • Glycine cleavage system P protein,
  • HYGN1,
  • EC 1.4.4.2,
  • NKH,
  • glycine cleavage system protein P,
  • GCSP,
  • GCE,
  • GLDC,
  • glycine decarboxylase P-protein,
  • glycine dehydrogenase [decarboxylating], mitochondrial,

Description…

From NCBI Gene: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: GLDC

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2