Early Detection Research Network

FOLH1

Aliases:
This biomarker is also known as:
  • FGCP,
  • folylpoly-gamma-glutamate carboxypeptidase,
  • Cell growth-inhibiting gene 27 protein,
  • FOLH,
  • prostate specific membrane antigen variant F,
  • EC 3.4.17.21,
  • pteroylpoly-gamma-glutamate carboxypeptidase,
  • Prostate-specific membrane antigen,
  • Membrane glutamate carboxypeptidase,
  • FOLH1,
  • folate hydrolase (prostate-specific membrane antigen) 1,
  • Glutamate carboxypeptidase II,
  • NAALAdase,
  • GCP2,
  • glutamate carboxypeptidase 2,
  • GCPII,
  • PSM,
  • Folate hydrolase 1,
  • Pteroylpoly-gamma-glutamate carboxypeptidase,
  • mGCP,
  • cell growth-inhibiting gene 27 protein,
  • N-acetylated alpha-linked acidic dipeptidase 1,
  • N-acetylated-alpha-linked acidic dipeptidase I,
  • glutamate carboxypeptidase II,
  • NAALADase I,
  • glutamate carboxylase II,
  • PSMA,
  • Folylpoly-gamma-glutamate carboxypeptidase,
  • NAALAD1,
  • membrane glutamate carboxypeptidase,

Description…

From NCBI Gene: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: FOLH1

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2