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FHIT

Basics

Aliases:
This biomarker is also known as:
  • diadenosine 5',5'''-P1,P3-triphosphate hydrolase,
  • FRA3B,
  • AP3Aase,
  • tumor suppressor protein,
  • Fragile histidine triad protein,
  • Diadenosine 5',5'''-P1,P3-triphosphate hydrolase,
  • EC 3.6.1.29,
  • bis(5'-adenosyl)-triphosphatase,
  • Dinucleosidetriphosphatase,
  • fragile histidine triad gene,
  • dinucleosidetriphosphatase,
  • AP3A hydrolase,

View in BioMuta

Description…

FHIT, or fragile histidine triad, is a member of the histidine triad gene family. The FHIT protein is a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Included in the FHIT gene is the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. Mutated transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. There are several alternatively spliced transcript variants for this gene.

Attributes

QA State: Under Review
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement