Early Detection Research Network

FAS

Aliases:
This biomarker is also known as:
  • tumor necrosis factor receptor superfamily member 6,
  • Apo-1 antigen,
  • Delta Fas/APO-1/CD95,
  • FASLG receptor,
  • ALPS1A,
  • Fas AMA,
  • CD95 antigen,
  • TNFRSF6,
  • Apoptosis-mediating surface antigen FAS,
  • APT1,
  • apoptosis-mediating surface antigen FAS,
  • FAS1,
  • CD95,
  • FAS 827dupA,
  • FASTM,
  • APO-1,
  • FAS (Ab2),
  • APO-1 cell surface antigen,
  • FAS,
  • apoptosis antigen 1,
  • Fas (TNF receptor superfamily, member 6),
  • tumor necrosis factor receptor superfamily, member 6,
  • FAS (Ab1),

Description…

FAS is a member of the TNF-receptor superfamily. The FAS protein is a receptor for TNFSF6/FASLG and has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: FAS

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Three
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2