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FAS

Basics

Aliases:
This biomarker is also known as:
  • apoptosis-mediating surface antigen FAS,
  • apoptosis antigen 1,
  • tumor necrosis factor receptor superfamily member 6,
  • FAS 827dupA,
  • Apoptosis-mediating surface antigen FAS,
  • ALPS1A,
  • TNFRSF6,
  • FAS1,
  • APO-1 cell surface antigen,
  • Fas (TNF receptor superfamily, member 6),
  • Fas AMA,
  • Apo-1 antigen,
  • tumor necrosis factor receptor superfamily, member 6,
  • Delta Fas/APO-1/CD95,
  • FAS (Ab1),
  • FASTM,
  • CD95 antigen,
  • APT1,
  • FAS (Ab2),
  • FASLG receptor,
  • APO-1,
  • CD95,

View in BioMuta

Description…

FAS is a member of the TNF-receptor superfamily. The FAS protein is a receptor for TNFSF6/FASLG and has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

FAS was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Ovary

Attributes

Phase: Three
QA State: Under Review

Overview

APO-1/Fas receptor (FasR) is a cell surface receptor that, when activated, triggers apoptosis. It has been postulated that this receptor may be involved in the clearance of benign ovarian epithelial inclusion cysts (IC). An observed decreased expression of FasR in malignant ovarian epithelial neoplasms as compared with benign ovarian epithelial lesions suggests that a decreased sensitivity to Fas-mediated apoptosis may be involved in ovarian epithelial carcinogenesis.

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement