Aliases:This biomarker is also known as:
Des-ubiquitin is formed when a cysteine protease cleaves two carboxy-terminal glycine residues from ubiquitin.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
Cathepsin B, which is a cysteine protease, cleaves 2 terminal glycine residues of ubiquitin generating des-ubiquitin. Both monomeric ubiquitin and des-ubiquitin corresponding to m/z values 8,565 and 8,451 are among the 9 candidates of the signature described in the Rahman 9-marker MALDI MS panel for Lung Cancer study.
Des-ubiquitin belongs to a 9-member panel that provides a quantitative measure of the probability of having lung cancer that goes beyond the histological evaluation of preinvasive lesions. The identified members of the panel are TMSB4X (Thymosin beta-4), Ubiquitin, des-ubiquitin, ACBP, CSTA, Cytochrome C, and MIF.
External Resources for Des-ubiquitin
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