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DEFB1

Basics

Aliases:
This biomarker is also known as:
  • HBD-1,
  • BD-1,
  • HBD1,
  • defensin, beta 1,
  • BD1,
  • P60022,
  • Defensin, beta 1,
  • DEFB-1,
  • beta-defensin-1,
  • hBD-1,
  • DEFB101,
  • beta-defensin 1,

View in BioMuta

Description…

DEFB1 is a member of the defensin family of microbicidal and cytotoxic peptides made by neutrophils. DEFB1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. DEFB1 is thought to be involved in the pathogenesis of cystic fibrosis.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

No additional ovarian data available.

Performance Comment

DEFB1 was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. DEFB1 was not in the group of 13 selected for further validation.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement