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DCC

Basics

Aliases:
This biomarker is also known as:
  • colorectal cancer suppressor,
  • tumor suppressor protein DCC,
  • deleted in colorectal cancer protein,
  • immunoglobulin superfamily DCC subclass member 1,
  • Immunoglobulin superfamily DCC subclass member 1,
  • Colorectal cancer suppressor,
  • netrin receptor DCC,
  • CRC18,
  • colorectal tumor suppressor,
  • CRCR1,
  • IGDCC1,
  • deleted in colorectal carcinoma,
  • immunoglobulin superfamily, DCC subclass, member 1,
  • Tumor suppressor protein DCC,

View in BioMuta

Description…

DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Attributes

QA State: Under Review
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 03/06/2014

Thank you to everyone who helped make the 27th EDRN Steering Committee Meeting a success. We look forward to seeing everyone at the 9th EDRN Scientific Workshop from September 8-11, 2014 in Washington D.C.

Announcement