Early Detection Research Network

CXCL8

Aliases:
This biomarker is also known as:
  • GCP-1,
  • NAP-1,
  • C-X-C motif chemokine 8,
  • NAF,
  • T cell chemotactic factor,
  • chemokine (C-X-C motif) ligand 8,
  • GCP1,
  • beta-thromboglobulin-like protein,
  • emoctakin,
  • small inducible cytokine subfamily B, member 8,
  • LECT,
  • T-cell chemotactic factor,
  • neutrophil-activating peptide 1,
  • IL8,
  • LUCT,
  • Monocyte-derived neutrophil-activating peptide,
  • IL-8,
  • AMCF-I,
  • interleukin 8,
  • interleukin-8,
  • CXCL8,
  • Granulocyte chemotactic protein,
  • lymphocyte-derived neutrophil-activating factor,
  • MDNCF,
  • 3-10C,
  • Neutrophil-activating protein 1,
  • LYNAP,
  • Protein 3-10C,
  • Emoctakin,
  • OTTHUMP00000199825,
  • MONAP,
  • NAP1,

Description…

CXCL8, commonly known as IL8, is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that attracts neutrophils, basophils, and T-cells, but not monocytes. IL8 is one of the major mediators of the inflammatory response, and is involved in neutrophil activation. It is released from several types of cells in response to an inflammatory stimulus. IL8 also functions as an angiogenic factor. The IL8 gene maps to chromosome 4q, and is found in a chemokine gene cluster along with ten other members of the CXC chemokine gene family. There are several N-terminal processed forms that are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. Among the forms are: IL-8(1-77), IL-8(5-77), IL-8(6-77), IL-8(7-77), IL-8(8-77), IL-8(9-77). IL-8(1-77) is generally referred to as interleukin 8. IL-8(6-77) is the most promiment form.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: CXCL8

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Attributes

Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2