Early Detection Research Network

Endostatin

Aliases:
This biomarker is also known as:
  • KS,
  • KNO,
  • COL18A1,
  • antiangiogenic agent,
  • collagen alpha-1(XVIII) chain,
  • human type XVIII collagen,
  • collagen, type XVIII, alpha 1,
  • Endostatin,
  • KNO1,
  • Knobloch syndrome, type 1,
  • multi-functional protein MFP,

Description…

COL18A1, also known as endostatin, is the alpha chain of type XVIII collagen. COL18A1 is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. It also inhibits endothelial cell proliferation and angiogenesis, and may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: COL18A1

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2