Early Detection Research Network

CDK5R1

Aliases:
This biomarker is also known as:
  • cyclin-dependent kinase 5, regulatory subunit 1 (p35),
  • Nck5a,
  • CDK5R,
  • Cyclin-dependent kinase 5 regulatory subunit 1,
  • p25,
  • p23,
  • p35,
  • TPKII regulatory subunit,
  • CDK5 activator 1,
  • p35nck5a,
  • tau protein kinase II 23kDa subunit,
  • CDK5P35,
  • cyclin-dependent kinase 5 regulatory subunit 1,
  • CDK5R1,
  • neuronal CDK5 activator,
  • cyclin-dependent kinase 5 activator 1,
  • NCK5A,
  • regulatory partner for CDK5 kinase,

Description…

From NCBI Gene: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Protein
HGNC Name: CDK5R1

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2