Boeri miRNA signature of diagnosis of lung cancer
miRNA expression analyses in plasma samples collected 1ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å"2 y before the onset of disease, at the time of CT detection and in disease-free smokers enrolled in the screening trial, resulted in the generation of miRNA signatures with strong predictive, diagnostic, and prognostic potential (area under the ROC curve ÃƒÂ¢Ã¢â‚¬Â°Ã‚Â¥ 0.85). The signature of diagnosis of lung cancer is comprised of 16 ratios composed from 13 miRNAs: 21, 92a, 140-3p, 17, 106a, 140-5p, 660, 19b, 451, 30c, 15b, 28-3p, 486-5p.
No member markers defined for this panel.
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The following organs have data associated with this biomarker…
Overall, these findings strengthen the observation that circulating miRNA in plasma is detectable well before clinical disease detection by spiral CT, indicating the possibility to select high-risk groups on the basis of miRNA profiling.
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