Bajtarevic VOCs signature
Aliases:This biomarker is also known as:
Exhaled breath was collected and differences in concentration for more than 50 volatile organic compounds (VOCs) was assayed by various methods.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
Solid phase microextraction with subsequent gas chromatography mass spectrometry (SPME-GCMS) and proton transfer reaction mass spectrometry (PTR-MS) complement each other, each method having its particular advantages and disadvantages. Exhaled breath analysis is promising to become a future non-invasive lung cancer screening method.
A comparison of the GCMS-results of 65 lung cancer patients with those of 31 healthy volunteers revealed differences in concentration for more than 50 compounds. Sensitivity for detection of lung cancer patients based on presence of (one of) 4 different compounds not arising in exhaled breath of healthy volunteers was 52% with a specificity of 100%. Using 15 (or 21) different compounds for distinction, sensitivity was 71% (80%) with a specificity of 100%. Potential marker compounds are alcohols, aldehydes, ketones and hydrocarbons.
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