Early Detection Research Network

APAF1

Aliases:
This biomarker is also known as:
  • APAF-1,
  • APAF1,
  • CED4,
  • KIAA0413,
  • apoptotic protease activating factor,
  • apoptotic peptidase activating factor 1,
  • apoptotic protease-activating factor 1,
  • apoptotic peptidase activating factor,

Description…

From NCBI Gene: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: APAF1

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2