Aliases:This biomarker is also known as:
- apoptotic protease activating factor,
- apoptotic protease-activating factor 1,
- apoptotic peptidase activating factor 1,
- apoptotic peptidase activating factor,
APAF1 is a cytoplasmic protein that initiates apoptosis. APAF1 binds cytochrome c and dATP, forming an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
No additional breast data available.
APAF1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Development and validation of sandwich ELISA microarrays with minimal assay interference.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.