Early Detection Research Network

AGR2

Aliases:
This biomarker is also known as:
  • PDIA17,
  • XAG-2,
  • hAG-2,
  • GOB-4,
  • HPC8,
  • secreted cement gland homolog,
  • Secreted cement gland protein XAG-2 homolog,
  • AG2,
  • protein disulfide isomerase family A, member 17,
  • anterior gradient homolog 2,
  • AG-2,
  • AGR2,
  • secreted cement gland protein XAG-2 homolog,
  • anterior gradient 2 homolog (Xenopus laevis),
  • HAG-2,
  • anterior gradient protein 2 homolog,

Description…

From NCBI Gene: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Under Review
Type: Gene
HGNC Name: AGR2

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

Version 5.0.2