Early Detection Research Network

ACO1

Aliases:
This biomarker is also known as:
  • iron-responsive element-binding protein 1,
  • iron-responsive element binding protein 1,
  • Iron regulatory protein 1,
  • Aconitase,
  • Iron-responsive element-binding protein 1,
  • citrate hydro-lyase,
  • Citrate hydro-lyase,
  • IREBP1,
  • IREB1,
  • aconitase 1, soluble,
  • ACONS,
  • IRP1,
  • cytoplasmic aconitate hydratase,
  • Ferritin repressor protein,
  • IREBP,
  • EC 4.2.1.3,
  • IRE-BP 1,
  • iron regulatory protein 1,
  • ACO1,
  • ferritin repressor protein,
  • aconitate hydratase,

Description…

From NCBI Gene: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Gene
HGNC Name: ACO1

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.

No other associated resources found.

Version 5.0.2