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You are here: Home / Biomarkers / ZFP36L1

ZFP36L1

Basics

Aliases:
This biomarker is also known as:
  • RNF162B,
  • zinc finger protein 36, C3H1 type-like 1,
  • BERG36,
  • butyrate response factor 1,
  • zinc finger protein 36, C3H type-like 1,
  • early response factor Berg36,
  • EGF-response factor 1,
  • cMG1,
  • TIS11B,
  • Berg36,
  • Protein TIS11B,
  • BRF1,
  • zinc finger protein, C3H type, 36-like 1,
  • Butyrate response factor 1,
  • ERF-1,
  • ERF1,

Description…

ZFP36L1 is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The ZFP36L1 gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. ZFP36L1 contains a putative zinc finger domain with a repeating cys-his motif. ZFP36L1 is believed to be a nuclear transcription factor most likely functioning in regulating the response to growth factors. Different isoforms encoded by alternatively spliced transcript variants have been isolated.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ZFP36L1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

ZFP36L1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: ZFP36L1
UniProt Accession #: Q07352
Mutated Sites Count: 90
Associated Pubmed ID Count 6
CancerDO Count 20
Affected Protein Function Sites Count: 1

View in BioMuta