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YEATS4

Basics

Aliases:
This biomarker is also known as:
  • nuMA-binding protein 1,
  • Glioma-amplified sequence 41,
  • 4930573H17Rik,
  • NuBI1,
  • NuMA binding protein 1,
  • GAS41,
  • NuBI-1,
  • YEATS domain-containing protein 4,
  • glioma-amplified sequence 41,
  • glioma-amplified sequence-41,
  • nuBI1,
  • NUBI-1,
  • NuMA-binding protein 1,
  • Gas41,
  • YAF9,
  • YEATS domain containing 4,
  • B230215M10Rik,

Description…

YEATS4 has high sequence similarity to human MLLT1, and yeast and human MLLT3 proteins, both transcription factors, and is therefore hypothesized to be a transcription factor itself. YEATS4 is thought to be required for RNA transcription. YEATS4 is also a component of the NuA4 histone acetyltransferase (HAT) complex.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: YEATS4

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

YEATS4 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

External Resources for YEATS4

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene

Protein

Other

No other associated resources found.

Biomuta

Mutation Statistics

Gene Name: YEATS4
UniProt Accession #: O95619
Mutated Sites Count: 29
Associated Pubmed ID Count 3
CancerDO Count 13
Affected Protein Function Sites Count: 4

View in BioMuta