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XPOT

Basics

Aliases:
This biomarker is also known as:
  • XPO3,
  • exportin-T,
  • exportin(tRNA),
  • Exportin(tRNA),
  • tRNA exportin,
  • exportin, tRNA (nuclear export receptor for tRNAs),

Description…

XPOT, or exportin-T, belongs to the RAN-GTPase exportin family. This protein facilitates export of tRNA from the nucleus to the cytoplasm. XPOT shuttles between the nucleus and the cytoplasm, transporting the aminoacylated tRNAs out of the nucleus, and returning back for another round.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: XPOT

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

XPOT was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: XPOT
UniProt Accession #: O43592
Mutated Sites Count: 129
Associated Pubmed ID Count 19
CancerDO Count 25
Affected Protein Function Sites Count: 5

View in BioMuta