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HE4

Basics

Aliases:
This biomarker is also known as:
  • EDDM4,
  • Major epididymis-specific protein E4,
  • WAP four-disulfide core domain 2 [Precursor],
  • WAP domain containing protein HE4-V4,
  • WAP5,
  • epididymis-specific, whey-acidic protein type, four-disulfide core,
  • WFDC2,
  • dJ461P17.6,
  • WAP four-disulfide core domain 2,
  • Putative protease inhibitor WAP5,
  • epididymal protein 4,
  • Epididymal secretory protein E4,

Description…

11 kDa protein that is a precursor to the epididymal secretory protein HE4; an inhibitor of an as yet unidentified protease. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.

Attributes

QA State: Accepted
Type: Protein
Short Name:
HGNC Name: WFDC2

Organs

The following organs have data associated with this biomarker…

Lung

Attributes

Phase: Two
QA State: Under Review

Overview

Performance Comment

Supporting Study Data

The following studies/protocols provide evidence supporting HE4 indications for the Lung…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

No organ-specific publications defined.

Organ-Specific Resources

No organ-specific resources defined.

Ovary

Attributes

Phase: Three
QA State: Accepted

Overview

Selected for study because of upregulation (mRNA) and overexpression (protein) studies in ovarian cancer.

Performance Comment

Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. HE4 alone was not a strong predictor. In 2009 HE4 was FDA approved to monitor for ovarian cancer recurrence, but not for early detection.

Supporting Study Data

The following studies/protocols provide evidence supporting HE4 indications for the Ovary…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

Organ-Specific Resources

No organ-specific resources defined.

Studies

No associated studies or protocols found.

Biomuta

Mutation Statistics

Gene Name: WFDC2
UniProt Accession #: Q14508
Mutated Sites Count: 17
Associated Pubmed ID Count 1
CancerDO Count 9
Affected Protein Function Sites Count: 4

View in BioMuta