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Aberrant Vimentin DNA Methylation in Stool


This biomarker is also known as:
  • VIM,
  • Vimentin methylation in stool,
  • Vimentin, methylated,


The VIM gene encodes a member of the intermediate filament family. VIM proteins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. These intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton.


QA State: Curated
Type: Epigenetic
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Three
QA State: Curated


Vimentin has no known role in colon cancer, and the VIM gene is not even active in the normal colon. Increased DNA methylation is an epigenetic alteration that is common in human cancers and is often associated with transcriptional silencing. The vimentin gene is transcriptionally silent in normal epithelium. Studies shows that aberrant methylation of exon-1 sequences within the nontranscribed vimentin gene is a novel molecular biomarker of colon cancer and can be successfully detected in fecal DNA to identify nearly half of individuals with colon cancer.

Performance Comment

Vimentin is in the process of validation and sensitivity/specificity testing in a CLIA/CAP laboratory.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


Mutation Statistics

Gene Name: VIM
UniProt Accession #: P08670
Mutated Sites Count: 83
Associated Pubmed ID Count 15
CancerDO Count 23
Affected Protein Function Sites Count: 3

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