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Aberrant Vimentin DNA Methylation in Stool

Basics

Aliases:
This biomarker is also known as:
  • Vimentin, methylated,
  • VIM,
  • Vimentin methylation in stool,

Description…

The VIM gene encodes a member of the intermediate filament family. VIM proteins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. These intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton.

Attributes

QA State: Curated
Type: Epigenetic
Short Name:
HGNC Name: VIM

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Colon

Attributes

Phase: Three
QA State: Curated

Overview

Vimentin has no known role in colon cancer, and the VIM gene is not even active in the normal colon. Increased DNA methylation is an epigenetic alteration that is common in human cancers and is often associated with transcriptional silencing. The vimentin gene is transcriptionally silent in normal epithelium. Studies shows that aberrant methylation of exon-1 sequences within the nontranscribed vimentin gene is a novel molecular biomarker of colon cancer and can be successfully detected in fecal DNA to identify nearly half of individuals with colon cancer.

Performance Comment

Vimentin is in the process of validation and sensitivity/specificity testing in a CLIA/CAP laboratory.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: VIM
UniProt Accession #: P08670
Mutated Sites Count: 83
Associated Pubmed ID Count 15
CancerDO Count 23
Affected Protein Function Sites Count: 3

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