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VCAM1

Basics

Aliases:
This biomarker is also known as:
  • CD_antigen=CD106,
  • sV-CAM,
  • MGC99561,
  • CD106,
  • serum vascular cell adhesion protein 1,
  • DKFZp779G2333,
  • L1CAM,
  • vascular cell adhesion molecule 1,
  • sVCAM-1,
  • INCAM-100,

Description…

VCAM1, a single-pass type I membrane protein belonging to the Ig superfamily, is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. It mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 may play a role in the development of artherosclerosis and rheumatoid arthritis. VCAM1 is expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: VCAM1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: One
QA State: Curated

Overview

No additional data available.

Performance Comment

Ninety biomarkers were measured using a series of multiplexed immunoassays and results analyzed by the EDRN data management center splitting the cases and controls into training and validation sets, excluding subjects with DCIS or atypical hyperplasia from the training phase. We found little evidence that any of these markers can discriminate women with invasive cancer from those with benign breast conditions.

Ovary

Attributes

Phase: Three
QA State: Curated

Overview

VCAM1 alone was not a strong predictor of ovarian cancer.

Performance Comment

Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. VCAM1 alone was not a strong predictor.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

No associated publications found.

Biomuta

Mutation Statistics

Gene Name: VCAM1
UniProt Accession #: P19320
Mutated Sites Count: 330
Associated Pubmed ID Count 21
CancerDO Count 25
Affected Protein Function Sites Count: 5

View in BioMuta