Aliases:This biomarker is also known as:
- prealbumin, amyloidosis type I,
Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid, is a carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. TT consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
In laboratory testing, transthyretin, in a panel (including apolipoprotein A-1, transferrin, and CA125) has been shown to be a highly sensitive (96%) predictor of early stage ovarian cancer and endometrial cancer.
Of the 28 ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. Top markers in phase II specimens included CA125, HE4, transthyretin, CA15.3, and CA72.4 with sensitivity at 95% specificity ranging from 0.73 to 0.40. Except for transthyretin, these markers had similar or better sensitivity when moving to phase III specimens that had been drawn within 6 months of the clinical diagnosis.
No associated publications found.
- HGNC entry for TTR from Genenames
- KEGG entry for TTR from Genome.jp
- Entrez entry for TTR all NCBI Databasese
- Human GEO Profiles for TTR from NCBI GEO Profiles
- Human Geo Datasets containing term TTR from NCBI GEO Datasets
- GWAS Study Datasets containing gene TTR from GWAS
- Human Single Nucleotide Polymorphisms info for TTR
- Human Gene(s) with 'TTR' as Gene Name/Alias
- Human Gene RefSeq for TTR from NCBI
- UniProtKB/Swiss-Prot entry for TTR from Uniprot
- Human Protein RefSeq for TTR from NCBI
- FDA web page describing approval of TTR
No other associated resources found.
|UniProt Accession #:||P02766|
|Mutated Sites Count:||27|
|Associated Pubmed ID Count||4|
|Affected Protein Function Sites Count:||4|