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TSHB

Basics

Aliases:
This biomarker is also known as:
  • Thyroid-stimulating hormone subunit beta,
  • thyrotropin subunit beta,
  • TSH-BETA,
  • TSH,
  • TSH-beta,
  • thyroid stimulating hormone, beta,
  • Thyrotropin beta chain,
  • INN=Thyrotropin alfa,
  • TSH-B,
  • CHNG4,
  • thyrotropin beta subunit,
  • Thyrotropin alfa,

Description…

TSH, a secreted protein belonging to the glycoprotein hormones subunit beta family, is essential for the control of thyroid structure and metabolism. The four human glycoprotein hormones - chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH)- are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Congenital hypothyroidism is caused by mutation in the TSH gene.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: TSHB

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Curated

Overview

TSHB alone was not shown to be a strong predictor of ovarian cancer.

Performance Comment

Of the ovarian cancer biomarkers tested in prediagnostic specimens, from the PLCO, CA125 remains the single best biomarker for ovarian cancer and has its strongest signal within six months of diagnosis. TSHB alone was not a strong predictor.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

No associated publications found.

Biomuta

Mutation Statistics

Gene Name: TSHB
UniProt Accession #: P01222
Mutated Sites Count: 48
Associated Pubmed ID Count 7
CancerDO Count 12
Affected Protein Function Sites Count: 5

View in BioMuta