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TRAF4

Basics

Aliases:
This biomarker is also known as:
  • Metastatic lymph node gene 62 protein,
  • cysteine-rich domain associated with RING and Traf domains protein 1,
  • MLN 62,
  • malignant 62,
  • Cysteine-rich domain associated with RING and Traf domains protein 1,
  • tumor necrosis receptor-associated factor 4A,
  • RNF83,
  • MLN62,
  • metastatic lymph node gene 62 protein,
  • RING finger protein 83,
  • cysteine-rich domain associated with ring and TRAF domain,
  • CART1,
  • TNF receptor-associated factor 4,

View in BioMuta

Description…

TRAF4 is a member of the TNF receptor associated factor (TRAF) family. Members of the TRAF family are the major signal transducers for the TNF receptor (TNFR) superfamily and the interleukin-1 receptor/Toll-like receptor superfamily. TRAF4 is involved in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: TRAF4

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

The TRAF4 gene is amplified in breast carcinoma. TRAF4 is also involved in the regulation of the TGF-β pathway and in subsequent breast cancer pathogenesis.

Performance Comment

TRAF4 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 02/12/2015

Please register for the 29th EDRN Steering Committee Meeting in Atlanta, GA from March 31-April 2, 2015. The registration page has information about booking hotel rooms and a draft agenda of the meeting.

Announcement