Aliases:This biomarker is also known as:
- Keratinocyte transcription factor KET,
- tumor protein 63,
- Transformation-related protein 63,
- Chronic ulcerative stomatitis protein,
- amplified in squamous cell carcinoma,
- tumor protein p63,
- tumor protein p63 deltaN isoform delta,
- tumor protein p53-like,
- tumor protein p53-competing protein,
- Tumor protein p73-like,
TP63 is a member of the p53 family of transcription factors. It acts as a sequence specific DNA binding transcriptional activator or repressor. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis.
|QA State:||Under Review|
There are no datasets associated with this biomarker.