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TNFRSF1B

Basics

Aliases:
This biomarker is also known as:
  • TNFri,
  • INN=Etanercept,
  • TNFBR,
  • TNFR-II,
  • tumor necrosis factor binding protein 2,
  • CD120b,
  • Tumor necrosis factor receptor 2,
  • TNFr2,
  • p80 TNF-alpha receptor,
  • TNFR1B,
  • TBPII,
  • CD120b antigen,
  • Tumor necrosis factor receptor type II,
  • CD_antigen=CD120b,
  • tumor necrosis factor beta receptor,
  • TNF-R2,
  • TNF-R-II,
  • soluble TNFR1B variant 1,
  • TNF-RII,
  • p75TNFR,
  • tumor necrosis factor receptor superfamily, member 1B,
  • TNFR80,
  • TNF-R75,
  • TNFR2,
  • p75,
  • Etanercept,

View in BioMuta

Description…

TNFRSF1B, also known as TNFr2, a single-pass type I member of the TNF-receptor superfamily, forms a heterocomplex with TNF-receptor 1 that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Although the function of IAPs in TNF-receptor signalling is unknown, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest that TNFr2 plays a role in protecting neurons from apoptosis by stimulating antioxidative pathways.

Attributes

QA State: Under Review
Type: Protein
Short Name:
HGNC Name: TNFRSF1B

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 02/12/2015

Please register for the 29th EDRN Steering Committee Meeting in Atlanta, GA from March 31-April 2, 2015. The registration page has information about booking hotel rooms and a draft agenda of the meeting.

Announcement