Aliases:This biomarker is also known as:
- prothymosin beta-4,
- T beta-4,
- thymosin beta 4, X-linked,
- thymosin beta-4,
- thymosin, beta 4, X chromosome,
- thymosin Î²4,
TMSB4X, or thymosin beta-4, belongs to the thymosin beta family. It is an actin sequestering protein which plays an important role in the regulation of actin polymerization. TMSB4X binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. It is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
Overexpression of thymosin beta-4 in tumors has been suggested to stimulate lung tumor metastasis by activating cell migration and angiogenesis. The gene expression of thymosin beta-4 was also significantly associated with metastasis in NSCLC patients and it was suggested as a prognostic parameter for NSCLC.
Thymosin beta-4 belongs to a 9-member panel that provides a quantitative measure of the probability of having lung cancer that goes beyond the histological evaluation of preinvasive lesions. The identified members of the panel are TMSB4X (Thymosin beta-4), Ubiquitin, des-ubiquitin, ACBP, CSTA, Cytochrome C, and MIF.
- HGNC entry for TMSB4X from Genenames
- KEGG entry for TMSB4X from Genome.jp
- Entrez entry for TMSB4X all NCBI Databasese
- Human GEO Profiles for TMSB4X from NCBI GEO Profiles
- Human Geo Datasets containing term TMSB4X from NCBI GEO Datasets
- GWAS Study Datasets containing gene TMSB4X from GWAS
- Human Single Nucleotide Polymorphisms info for TMSB4X
- Human Gene(s) with 'TMSB4X' as Gene Name/Alias
- Human Gene RefSeq for TMSB4X from NCBI
- GeneCards entry for human TMSB4X
- UniProtKB/Swiss-Prot entry for TMSB4X from Uniprot
- Human Protein RefSeq for TMSB4X from NCBI
- FDA web page describing approval of TMSB4X
No other associated resources found.
|UniProt Accession #:||P62328|
|Mutated Sites Count:||6|
|Associated Pubmed ID Count||0|
|Affected Protein Function Sites Count:||3|