TLR2
Basics
Aliases:
This biomarker is also known as:- CD282,
- toll-like receptor 2,
- Toll/interleukin-1 receptor-like protein 4,
- TIL4,
- toll/interleukin-1 receptor-like protein 4,
- CD282 antigen,
- toll/interleukin 1 receptor-like 4,
Description…
TLR2, or toll-like receptor 2, is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is involved in the innate immune response to bacterial lipoproteins and other microbial cell wall components. TLR2 also plays a role in NF-kappa-B activation, cytokine secretion and the inflammatory response.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | TLR2 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
TLR2 gene polymorphisms have been related to increased susceptibility to cancer development in various organs, including breast cancer.
Performance Comment
TLR2 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer.
- Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
- Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk.
Resources
External Resources for TLR2
Gene
- Entrez entry for TLR2 all NCBI Databasese
- Find Human Single Nucleotide Polymorphisms info for TLR2
- Human Gene(s) with 'TLR2' as Gene Name/Alias
- GeneCards entry for human TLR2
Protein
Other
No other associated resources found.
Biomuta
Mutation Statistics
| Gene Name: | TLR2 |
|---|---|
| UniProt Accession #: | O60603 |
| Mutated Sites Count: | 139 |
| Associated Pubmed ID Count | 19 |
| CancerDO Count | 22 |
| Affected Protein Function Sites Count: | 6 |
