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TLR2

Basics

Aliases:
This biomarker is also known as:
  • toll/interleukin-1 receptor-like protein 4,
  • Toll/interleukin-1 receptor-like protein 4,
  • CD282 antigen,
  • toll/interleukin 1 receptor-like 4,
  • TIL4,
  • toll-like receptor 2,
  • CD282,

Description…

TLR2, or toll-like receptor 2, is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is involved in the innate immune response to bacterial lipoproteins and other microbial cell wall components. TLR2 also plays a role in NF-kappa-B activation, cytokine secretion and the inflammatory response.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: TLR2

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

TLR2 gene polymorphisms have been related to increased susceptibility to cancer development in various organs, including breast cancer.

Performance Comment

TLR2 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: TLR2
UniProt Accession #: O60603
Mutated Sites Count: 140
Associated Pubmed ID Count 20
CancerDO Count 24
Affected Protein Function Sites Count: 6

View in BioMuta