TLR2
Basics
Aliases:
This biomarker is also known as:- CD282 antigen,
- toll-like receptor 2,
- Toll/interleukin-1 receptor-like protein 4,
- toll/interleukin-1 receptor-like protein 4,
- CD282,
- TIL4,
- toll/interleukin 1 receptor-like 4,
Description…
TLR2, or toll-like receptor 2, is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is involved in the innate immune response to bacterial lipoproteins and other microbial cell wall components. TLR2 also plays a role in NF-kappa-B activation, cytokine secretion and the inflammatory response.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Protein |
| Short Name: | |
| HGNC Name: | TLR2 |
Datasets
There are no datasets associated with this biomarker.
Organs
The following organs have data associated with this biomarker…
Breast
Attributes
| Phase: | Two |
|---|---|
| QA State: | Under Review |
Overview
TLR2 gene polymorphisms have been related to increased susceptibility to cancer development in various organs, including breast cancer.
Performance Comment
TLR2 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
- Standardizing diagnostic markers to evaluate and compare their performance.
- Prognostic significance of occult tumor cells in the apheresis products of patients with advanced breast cancer receiving high-dose chemotherapy and autologous hematopoietic progenitor cell support.
- Longitudinal assessment of urinary PCA3 for predicting prostate cancer grade reclassification in favorable-risk men during active surveillance.
Resources
External Resources for TLR2
Gene
- Entrez entry for TLR2 all NCBI Databasese
- Find Human Single Nucleotide Polymorphisms info for TLR2
- Human Gene(s) with 'TLR2' as Gene Name/Alias
- GeneCards entry for human TLR2
Protein
Other
No other associated resources found.
Biomuta
Mutation Statistics
| Gene Name: | TLR2 |
|---|---|
| UniProt Accession #: | O60603 |
| Mutated Sites Count: | 117 |
| Associated Pubmed ID Count | 19 |
| CancerDO Count | 23 |
| Affected Protein Function Sites Count: | 2 |
