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TIMP1

Basics

Aliases:
This biomarker is also known as:
  • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor),
  • CLGI,
  • TIMP metallopeptidase inhibitor 1,
  • Fibroblast collagenase inhibitor,
  • metalloproteinase inhibitor 1,
  • Tissue inhibitor of metalloproteinases 1,
  • Erythroid-potentiating activity,
  • EPO,
  • TIMP,
  • HCI,
  • Collagenase inhibitor,
  • TIMP-1,

View in BioMuta

Description…

The TIMP1 protein encoded by this TIMP gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of the TIMP1 gene is highly inducible in response to many cytokines and hormones. Metalloproteinase 1 is a stromal factor with multiple functions. Overexpression reduces pancreatic cancer cell implantation, growth, metastasis, and angiogenesis, while increasing tumor apoptosis, all without altering metallopeptidase 2 production.

Attributes

QA State: Under Review
Type: Protein
Short Name:
HGNC Name: TIMP1

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 Steering Committee Meeting

The next EDRN Steering Committee Meeting will take place March 31st through April 2nd, 2015, in Atlanta, Georgia.

Announcement 02/12/2015

Please register for the 29th EDRN Steering Committee Meeting in Atlanta, GA from March 31-April 2, 2015. The registration page has information about booking hotel rooms and a draft agenda of the meeting.

Announcement