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THBS1

Basics

Aliases:
This biomarker is also known as:
  • THBS-1,
  • thrombospondin-1p180,
  • THBS,
  • TSP-1,
  • TSP,
  • Thrombospondin-1,

Description…

TSP is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. TSP can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. It has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.

Attributes

QA State: Accepted
Type: Protein
Short Name:
HGNC Name: THBS1

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: Two
QA State: Accepted

Overview

Blood protein markers that provide more accurate or earlier diagnosis of prostate cancer should have a positive impact on prostate cancer treatment and management. Experimental evidence shows that thrombospondin-1 levels are elevated in patients with benign prostatic disease and repressed in patients with prostate cancer. Thrombospondin-1 levels do not correlate with prostate-specific antigen (PSA) levels and differentiate benign from malignant disease with 79% sensitivity and 81% specificity. The measurement of thrombospondin-1 could be used to assist the decision to obtain a biopsy in men with suspected prostate cancer, which could lead to a reduction in the number of unnecessary prostatic biopsies.

Performance Comment

TSP did not, for the populations tested in these experiments, show strong pre-diagnostic performance. This biomarker has not moved on to Phase 3 study.

Supporting Study Data

The following studies/protocols provide evidence supporting THBS1 indications for the Prostate…

No supporting studies or protocols found.

Organ-Specific Protocols

No organ-specific protocols defined.

Organ-Specific Publications

Organ-Specific Resources

No organ-specific resources defined.

Studies

No associated studies or protocols found.

Biomuta

Mutation Statistics

Gene Name: THBS1
UniProt Accession #: P07996
Mutated Sites Count: 196
Associated Pubmed ID Count 20
CancerDO Count 26
Affected Protein Function Sites Count: 5

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