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STOML2

Basics

Aliases:
This biomarker is also known as:
  • HSPC108,
  • EPB72-like protein 2,
  • SLP-2,
  • SLP2,
  • stomatin (EPB72)-like 2,
  • stomatin-like 2,
  • stomatin-like protein 2,

Description…

STOML2, also known as SLP-2 or stomatin-like 2, is a mitochondrial protein that is thought to regulate the biogenesis and the activity of mitochondria, and through this regulation play a role in cell activities such as cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: STOML2

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

STOML2, also known as SLP-2 or stomatin-like 2, is overexpressed in many cancers, including breast cancer. STOML2 (SLP-2) expression and ERBB2 (HER-2/neu) protein expression are associated with decreased breast cancer patient survival.

Performance Comment

STOML2 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Biomuta

Mutation Statistics

Gene Name: STOML2
UniProt Accession #: Q9UJZ1
Mutated Sites Count: 39
Associated Pubmed ID Count 7
CancerDO Count 19
Affected Protein Function Sites Count: 1

View in BioMuta